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FANCD2 depleted Zebra Fish embryos are selectively sensitive to Gö6976. A graphical representation of zebrafish embryo viability following depletion of FANCD2 using an increasing concentration of a specific morpholino and treatment with Gö6976 (bars 2, 4, 6, 8, 10 and 12) or DMSO control (bars 1, 3, 5, 7, 9 and 11). Representative photographs of FANCD2 depleted embryos 24 hrs after Gö6976 treatment are shown. Gö6976 was used at a concentration of 0.5 uM.
To ensure that the hypersensitivity of FA deficient cells to
CHK1 inhibition was not an artifact of our cell model systems, we
used an in vivo, whole organism approach (Figure 5).
In the absence of FANCD2 morpholino, treatment with 1 uM of Gö6976
yielded no detectable phenotype ( and Figure 5).
Chen, Clark C; Kennedy, Richard D; Sidi, Samuel; Look, A Thomas; D'Andrea, AlanJournal: Molecular Cancer
Issue 1DOI: 10.1186/1476-4598-8-24Published: 2009-12-01Institution(s):
Dana-Farber Cancer Institute, Harvard Medical School, Beth Israel Hospital, Harvard Medical School
This image is from the article titled "CHK1 inhibition as a strategy for targeting fanconi anemia (FA) DNA repair pathway deficient tumors"
(from Molecular Cancer) which is copyrighted by Chen et al. For more information on the
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