Mechanism of action of tetanospasmin (tetanus toxin). a Retrograde intra-axonal transport, b blockade of inhibitory synapse (modified from Ref. )
Thus, presynaptic excitatory neurons become predominant, and the
frequency of the resting impulse discharges from α-motor neurons is
increased (continuous discharges of the motor units), causing
muscular hypertonicity, which progresses to tonic spasms
(Fig. 1) .
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