Immunolocalization of fibroblast growth factor receptor-3 (FGFR3) in osteophyte (a) and fetal growth plate (b). a Cellular staining for FGFR3 in the deep zone of osteophytes (representative picture, ×312.5; arrow shows positively stained chondrocyte). b Cellular staining for FGFR3 in proliferating, pre-, and hypertrophic chondrocytes (×100, arrowhead shows positively stained hypertrophic chondrocyte). c Negative control for FGFR3 using a fetal sample corresponding to b
Mostly, samples with some single positively stained cells were seen (Fig. 3 a; Table 1 ). .
The intensity of immunostaining decreased from hypertrophic to maturing, proliferating, and resting (no stain) chondrocytes (Fig. 3 b; Table 2 ).
However, one specimen with an area of intense staining for collagen type X in the deepest layer and with collagen type I and II showed a relatively intense staining for FGFR3 (see Fig. 3 a).
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