Immunolocalization of fibroblast growth factor receptor-3 (FGFR3) in osteophyte (a) and fetal growth plate (b). a Cellular staining for FGFR3 in the deep zone of osteophytes (representative picture, ×312.5; arrow shows positively stained chondrocyte). b Cellular staining for FGFR3 in proliferating, pre-, and hypertrophic chondrocytes (×100, arrowhead shows positively stained hypertrophic chondrocyte). c Negative control for FGFR3 using a fetal sample corresponding to b
Mostly, samples with some single positively stained cells were seen
(Fig. 3 a; Table 1 ). .
The intensity of immunostaining decreased from hypertrophic to
maturing, proliferating, and resting (no stain) chondrocytes
(Fig. 3 b; Table 2 ).
However, one specimen with an area of intense staining for collagen
type X in the deepest layer and with collagen type I and
II showed a relatively intense staining for FGFR3 (see Fig. 3
Viewing this image requires a subscription. If you are a subscriber, please log in.
This image is from the article titled "PTHrP, PTHr, and FGFR3 are involved in the process of endochondral ossification in human osteophytes"
(from Histochemistry and Cell Biology), which is copyrighted by Springer-Verlag. For more information on the
copyright for this image, please refer to the full image caption and to the
The image is being made available for non-commercial purposes for subscribers to SpringerImages. For more information on what you are allowed to do with this image, please see our copyright policy.
To request permissions to use any copyrighted material, please visit the source document.
Report a copyright concern regarding this image.
Log in or register to save your favorite images and download them as high-quality PowerPoint or PDF files.
Log in or register to save your search criteria.
© Springer, part of Springer Science+Business Media.
Remote Address: 18.104.22.168 Server: 21