Creutzfeldt-Jakob disease in a 60-year-old female with progressive dementia and a history of previous surgery for malignant meningioma repaired with cadaveric dura. The diagnosis was confirmed histologically by brain autopsy. a The T2-weighted MR image shows post-surgical changes, brain atrophy and mild to minimal hyperintensity in the caudate nuclei bilaterally and in the left cerebral cortex. b Diffusion-weighted MR imaging reveals restricted diffusion in the caudate nuclei and in the entire left cerebral cortex
A study on the extent and distribution of cortical signal intensity
changes in 39 patients with sporadic CJD revealed that no case was
completely confined to only one hemisphere ; however, changes
on the contralateral side might be subtle and they may be missed,
for example in the rare subtype of an iatrogenic transmission after
dura transplantation (Fig. 9). .
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