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Lungs from infected preterm lambs display similar trends in lymphocytic infiltration compared to full-term lambs. (A) Scoring of lymphocytes and plasma cells infiltration in the lung sections of each animal. (B) Perforin mRNA levels were measured by qPCR and expressed as fold induction relative to control animals of the same time point. (C) PD-L1 mRNA levels were measured by qPCR and expressed as fold induction relative to control animals of the same time point. For qPCR results, preliminary correlation analysis of qPCR data determined that the level of each mediator was similar between control animals of either age groups. The data represent the mean ± SE. *p < 0.05, **p < 0.01, ***p < 0.001 by ANOVA. NS, p > 0.05.
Scoring for lymphocytes and plasma cell infiltration revealed
that RSV infection induced comparable cellular recruitment in the
lung in both preterm and full-term lambs (Figure 6A).
The functional state of the lymphocytes was assessed through
perforin mRNA (Figure 6B), whose levels were induced by RSV.
Similar to the cellular infiltration, perforin mRNA was induced at
comparable levels regardless of the age of the infected animal
However, a comparison between age groups showed that PD-L1 levels
in RSV-infected preterm lambs were significantly higher than in
RSV-infected full-term lambs (Figure 6C).
Sow, Fatoumata B; Gallup, Jack M; Krishnan, Subramaniam; Patera, Andriani C; Suzich, JoAnn; Ackermann, Mark RJournal: Respiratory Research
Issue 1DOI: 10.1186/1465-9921-12-106Published: 2011-12-01Institution(s):
Iowa State University, MedImmune, LLC
This image is from the article titled "Respiratory syncytial virus infection is associated with an altered innate immunity and a heightened pro-inflammatory response in the lungs of preterm lambs"
(from Respiratory Research) which is copyrighted by Sow et al; licensee BioMed Central Ltd. For more information on the
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