Psoriasiform drug eruption. The biopsy from this eruption induced by a β-adrenoceptor antagonist demonstrates a neutrophil-rich scale-crust overlying an epidermis in which psoriasiform hyperplasia and an absent granular cell layer are cognate to psoriasis.
Skin biopsies of drug-associated lesions reveal many features
common to idiopathic psoriasis, including psoriasiform epidermal
hyperplasia, diminution of the granular cell layer, and foci of
neutrophil-containing parakeratosis (figure 13).
In this higher magnification view of the same biopsy demonstrated
in figure 13, there is pronounced tissue eosinophilia.
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