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IPMN of the gastric type showing severe cellular atypia and MUC5 positivity
The gastric type seems to be less aggressive, i.e., less invasive,
than the other IPMN subtypes [ 10 , 25 , 33 , 46 ] but may show
severe cellular atypia in a few cases (up to 25%) [ 46 ]
(Table 3 , Fig. 2 ) The size of the lesion was
unrelated to the grade of cellular atypia [ 46 ]. .
Andrejevic-Blant, Snezana; Kosmahl, Markus; Sipos, Bence; Klöppel, GünterJournal: Virchows Archiv
Issue 5DOI: 10.1007/s00428-007-0512-6Published: 2007-11-05Institution(s):
University of Lausanne, CHUV Hospital, University of Kiel
For a long time, intraductal tumors of the pancreas were neglected because they were misdiagnosed as mucinous cystadenocarcinoma, ordinary ductal adenocarcinoma, or chronic pancreatitis. Only in recent years have they been recognized as clinical and pathological entities. Most common are the intraductal papillary-mucinous neoplasms. Although they show an adenoma-carcinoma sequence, they have proved to have a more favorable prognosis than ductal adenocarcinoma, when resected in a preinvasive state. Recently, it has become clear that they constitute a heterogeneous group with at least four subtypes. Their stratification reveals that the various intraductal papillary-mucinous neoplasm subtypes have different biological properties with different prognostic implications.
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