Histology of selected other types of CNS tumors. (a) Meningeal melanocytoma composed of isomorphic melanocytic cells with abundant melanin pigmentation (H&E). (b) Capillary hemangioblastoma (WHO grade I). On H&E, these tumors are characterized by vacuolated stromal cells located in a dense network of capillary vessels (H&E). (c) Subependymal giant cell astrocytoma (WHO grade I). Histology shows a moderately cellular tumor composed of astrocytic cells with abundant eosinophilic cytoplasm and enlarged ganglion cell-like nuclei (H&E). (d) Variable expression of GFAP in a subendymal giant cell astrocytoma
(e) Adamantinous craniopha-ryngeoma (WHO grade I) pushing towards the adjacent brain tissue, which shows a strongly GFAP-positive reactive gliosis (right side). The actual craniopharyngeoma tissue (left side) is GFAP negative
(f) Xanthogranuloma of the sellar region. This lesion is characterized by a chronic inflammatory reaction with foreign body giant cells, hemorhages and cholesterol clefts (Masson trichrome stain). (g–h) Granular cell tumor of the neurohypophysis (WHO grade I). The H&E stain (g) shows a moderately cellular neuroepithelial tumor composed of isomorphic cells with somewhat granular cytoplasm. The tumor cells are strongly PAS positive (h)
(i–j) Primary intracerebral malignant non-Hodgkin lymphoma (PCNSL). On H&E (i), the tumor shows an angiocentric growth within the brain parenchyma. Immunohistochemically, PCNSL are usually positive for the B-cell marker CD20 (j)
1.13a) and others containing large amelanotic areas.
1.13e) resembles odontogenic tumors, particularly calcifying
odontogenic cyst and ameloblastoma..
1.13f) is a benign, typically intra-sellar lesion of young adults
that is histologically composed of cholesterol clefts, xanthoma
cells, chronic inflammatory cells, necroses, hemosiderin deposits
and occasionally a few epithelial cells..
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