Chromatograms obtained after drug exposition to: acid hydrolysis (a), alkaline hydrolysis (b) and oxidation (c), from 60 μg mL−1 solutions diluted on mobile phase. Each of them represent: sibutramine hydrochoride RS exposed (a), bulk sample exposed (b), and blank solution (c)
Figure 3 shows the chromatograms obtained after acid and
alkaline hydrolysis, and oxidation of sibutramine hydrochloride RS
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