SpringerImages - Phylogenetic analysis of selected eukaryotic CDK sequences. Phylogenetic tree of eukaryotic CDKs using Arabidopsis protein sequences, as well as selected sequences from animals and the Ph1 and related loci from wheat are shown as a black bar. CDKs function is indicated by the colour (online version) or symbols associated with each box: Yellow box/^ = cell cycle regulation; blue box/x = CDK activation; red box/* = mRNA processing (includes transcription, translation and splicing). The rounded rectangular boxes for AtCDKGs indicate that their involvement in mRNA processing is speculative. The letter “L” next to animal CDKs refers to the long isoforms of those proteins. The phylogenetic tree was constructed using the DNASTAR Lasergene software and protein sequence analysis was performed by Clustal-W method, using the default settings. Below the tree, the scale indicates the number of nucleotide substitutions for the studied protein sequences. (At A. thaliana, Triae T. aestivum, Hs H. sapiens, Rano R. norvegicus, Mmus M. musculus)

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Fig 4

Phylogenetic analysis of selected eukaryotic CDK sequences. Phylogenetic tree of eukaryotic CDKs using Arabidopsis protein sequences, as well as selected sequences from animals and the Ph1 and related loci from wheat are shown as a black bar. CDKs function is indicated by the colour (online version) or symbols associated with each box: Yellow box/^ = cell cycle regulation; blue box/x = CDK activation; red box/* = mRNA processing (includes transcription, translation and splicing). The rounded rectangular boxes for AtCDKGs indicate that their involvement in mRNA processing is speculative. The letter “L” next to animal CDKs refers to the long isoforms of those proteins. The phylogenetic tree was constructed using the DNASTAR Lasergene software and protein sequence analysis was performed by Clustal-W method, using the default settings. Below the tree, the scale indicates the number of nucleotide substitutions for the studied protein sequences. (At A. thaliana, Triae T. aestivum, Hs H. sapiens, Rano R. norvegicus, Mmus M. musculus)

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Interestingly, phylogenetic analysis of CDKs from Arabidopsis , human and the Ph1 locus shows that the Ph1 CDK cluster is adjacent to the Arabidopsis CDKGs and human CDK10/CDK11 proteins (Fig. 4 ).

Interestingly, Arabidopsis CDKG1 and CDKG2 genes are closely related to mammalian CDK10 and CDK11 (Fig. 4 ).

CKLs seem to be closely related to CDKC as these two groups are located in adjacent paraclades in a phylogenetic tree (Fig. 4 ).

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