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Western blotting show expression of both Kir6.1 and Kir6.2 KATPchannel pore-forming subunits in unstimulated and LPS/IFNγ-stimulated BV-2 cells (A, left) and microglial primary cultures (A, Right). Staining for the microglial cell membrane marker CD11b (B and E) and the KATPchannel subunits Kir 6.1 (C) or Kir 6.2 (F) showed colocalization in BV-2 microglia, indicating the expression of the KATPchannel at the cytoplasmic membrane (D and G, white arrows). Control: unstimulated cells; L+I: cells stimulated with LPS and IFNγ. Scale bar = 30 μm.
A strong signal for both subunits in all conditions was observed
(Figure 1A). .
Results showed co-localization of CD11b and both Kir6.X subunits
immunosignal at membrane level as well as in the cytosol (Figure
Virgili, Noemí; Espinosa-Parrilla, Juan F; Mancera, Pilar; Pastén-Zamorano, Andrea; Gimeno-Bayon, Javier; Rodríguez, Manuel J; Mahy, Nicole; Pugliese, MarcoJournal: Journal of Neuroinflammation
Issue 1DOI: 10.1186/1742-2094-8-149Published: 2011-12-01Institution(s):
Parc Científic de Barcelona, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)
This image is from the article titled "Oral administration of the KATP channel opener diazoxide ameliorates disease progression in a murine model of multiple sclerosis"
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