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Mitomycin C growth inhibition in lymphoblastoid cell lines from the 310 family. Black circle and square depicts cell lines derived from affected individuals with PALB2 1592delT mutation. Black triangle signs for control sample from healthy individual.
To test whether the previously described PALB2 c.1592delT mutation
has functional consequences also in a heterozygous form, as present
in all our patients, we predisposed two lymphoblast cell lines with
c.1592delT and a wild type carrying control cell line to DNA cross
linking agent MMC (Figure 2).
Pakkanen, Sanna; Wahlfors, Tiina; Siltanen, Sanna; Patrikainen, Mimmi; Matikainen, Mika P; Tammela, Teuvo LJ; Schleutker, JohannaJournal: Journal of Negative Results in BioMedicine
Issue 1DOI: 10.1186/1477-5751-8-12Published: 2009-12-01Institution(s):
Institute of Medical Technology, University of Tampere and Tampere University Hospital, Tampere University Hospital and Medical School, University of Tampere
This image is from the article titled "PALB2 variants in hereditary and unselected Finnish Prostate cancer cases"
(from Journal of Negative Results in BioMedicine) which is copyrighted by Pakkanen et al. For more information on the
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