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Expression of L1CAM in NSCLC. A/B) SCC with expression of L1CAM (*) whereas the bronchial ciliated and focally metaplastic epithelium is negative (**), magnification 200x. Note on Figure 1B the pronounced expression of L1CAM in some areas of the tumor-stroma interface. C/D) Serial section, C CD31 (endothelial cells marked by arrowheads) and D L1CAM, of a SCC surrounding and partially invading the media of a blood vessel. Note that intratumoral vessels regularly show profound remodeling of the arteriolar wall with disappearance of the elastic layers normally bordering the media myocytes, magnification 200x. E) L1CAM positive tumor cells (brown) destroying the vessel wall lined by CD31 positive (red) endothelial cells. F) Accentuated L1CAM expression at the tumor-stroma interface (dashed line) and weaker (heterogeneous) L1CAM expression in the lower part of the picture representing a central part of the tumor. Hematoxylin counterstain was used for all slides.
Normal lung tissue, endothelial cells and bronchial epithelium were
negative for L1CAM stained on whole sections (Figure 1A, B).
Examples of vessel infiltration and blood vessel tropism are shown
in Figure 1C-E.
L1CAM expression was found to be strongest at the tumor-stroma
interface (Figure 1B, F and 2A, B).
Expression of L1CAM was found to be heterogeneous in 63/468 (13.5%)
of cases which was confirmed in randomly selected cases by whole
sections (Figure 1F). .
On the whole sections, L1CAM was often found at the tumor-stroma
interface (Figure 1B, F and 2A, B) and E-cadherin in the tumor
center (Figure 2A-D).
Tischler, Verena; Pfeifer, Marco; Hausladen, Silke; Schirmer, Uwe; Bonde, Anne-Katrine; Kristiansen, Glen; Sos, Martin L; Weder, Walter; Moch, Holger; Altevogt, Peter; Soltermann, AlexJournal: Molecular Cancer
Issue 1DOI: 10.1186/1476-4598-10-127Published: 2011-12-01Institution(s):
University Hospital Zurich, German Cancer Research Center, University of Zurich, Max Planck Institute for Neurological Research with Klaus-Joachim-Zülch Laboratories of the Max Planck Society and the Medical Faculty of the University of Köln
This image is from the article titled "L1CAM protein expression is associated with poor prognosis in non-small cell lung cancer"
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