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Recrudescence ofP. falciparumin a traveller treated with artemether-lumefantrine (Riamet®, Novartis). The P. falciparum parasitaemia (% infected erythrocytes as filled circles) decreased promptly after artemether-lumefantrine treatment was initiated (day 0) and symptoms reappeared on day 21. The second episode was treated successfully with mefloquine. Plasma concentrations of artemether, dihydroartemisinin, lumefantrine and desbutyl lumefantrine were assessed on day 6 and day 25. Lumefantrine concentrations (open triangles) are shown in the graph whereas the other results are stated in the text.
The first dose was however delayed and parasitaemia peaked at 1.3%
before decreasing promptly during treatment (Figure 1).
Drug concentrations were measured by liquid chromatography
coupled to tandem mass-spectrometry (LC-MS/MS) in plasma collected
on day 6 and 25 after initiating artemether-lumefantrine
Färnert, Anna; Ursing, Johan; Tolfvenstam, Thomas; Rono, Josea; Karlsson, Lillemor; Sparrelid, Elda; Lindegårdh, NiklasJournal: Malaria Journal
Issue 1DOI: 10.1186/1475-2875-11-176Published: 2012-12-01Institution(s):
Karolinska Institutet, Karolinska University Hospital, Mahidol University, University of Oxford
This image is from the article titled "Artemether–lumefantrine treatment failure despite adequate lumefantrine day 7 concentration in a traveller with Plasmodium falciparum malaria after returning from Tanzania"
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