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Univariate and multivariate Cox regression analysis
Patient and tumor characteristics
Univariate Hazard Ratio (95% confidence interval)
Multivariate Hazard Ratio (95% confidence interval)
Age (median 68 year)
Tumor diameter (median 4.5 cm)
CK18-Asp396 plasma level P1
Total CK18 plasma level P1
CK18-Asp396/CK18 ratio P1
CK18-Asp396 plasma level P3
Total CK18 plasma level P3
CK18-Asp396/CK18 ratio P3
Cox hazards analysis of patient and tumor characteristics in relation to disease-free survival. Multivariate Cox hazards analysis of pre-operative or post-operative CK18-Asp396, total CK18 antigen level or CK18-Asp396/CK18 ratios combined with Dukes' stage. P ≤ 0.05 were considered significant, shown in bold.
Calculation of hazard ratios as estimates of relative risk of death
or disease recurrence is shown in Table 3.
High CK18-Asp396 levels as well as total CK18 plasma levels after
tumor resection were associated with worse disease-free survival
(Figure 3C and 3D), also found in the univariate Cox hazard
analysis (Table 3). .
These analyses showed that patients with high pre-operative
CK18-Asp396 plasma levels have a 3.6 times increased relative risk
of colorectal cancer-related-death or disease recurrence (Table 3),
independent of Dukes' staging.
Post-operative CK18-Asp396, total CK18 and CK18-Asp396/CK18 ratio
levels all had similar prognostic significance, although not
significant (Table 3)..
Koelink, Pim J; Lamers, Cornelis BHW; Hommes, Daan W; Verspaget, Hein WJournal: BMC Cancer
Issue 1DOI: 10.1186/1471-2407-9-88Published: 2009-12-01Institution(s):
Leiden University Medical Centre
This table is from the article titled "Circulating cell death products predict clinical outcome of colorectal cancer patients"
(from BMC Cancer) which is copyrighted by Koelink et al. For more information on the
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