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Overview of expression changes (intervention spread vs. control spread) of 706 probesets (P < 0.01 for BMI × treatment effect) in nine lean (L left side) and eight overweight (O right side) subjects
When plotting the expression changes (intervention spread versus
control spread) of this set of 706 genes in the lean and overweight
subjects (Fig. 2 ), it can be seen that the expression
changes are more pronounced (larger fold changes) in the lean
subjects than in the overweight subjects.
Erk, Marjan J.; Pasman, Wilrike J.; Wortelboer, Heleen M.; Ommen, Ben; Hendriks, Henk F. J.Journal: Genes & Nutrition
Issue 3DOI: 10.1007/s12263-008-0096-zPublished: 2008-12-02Institution(s):
TNO Quality of Life
The goal of this study was to investigate the effect of a short-term nutritional intervention on gene expression in adipose tissue from lean and overweight subjects. Gene expression profiles were measured after consumption of an intervention spread (increased levels of polyunsaturated fatty acids, conjugated linoleic acid and medium chain triglycerides) and a control spread (40 g of fat daily) for 9 days. Adipose tissue gene expression profiles of lean and overweight subjects were distinctly different, mainly with respect to defense response and metabolism. The intervention resulted in lower expression of genes related to energy metabolism in lean subjects, whereas expression of inflammatory genes was down-regulated and expression of lipid metabolism genes was up-regulated in the majority of overweight subjects. Individual responses in overweight subjects were variable and these correlated better to waist–hip ratio and fat percentage than BMI.
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