Intrinsic Dissolution Rates of Cocrystal Formers and Cocrystals at 37°C in Water (n = 3)
Presented in Table IV are the intrinsic dissolution rate
As expected for BCS Class II drugs, the two profens exhibit very
slow dissolution (Table IV), consistent with their low aqueous
solubilities (Table III).
However, when forming a cocrystal with NCT, both profens displayed
substantial enhancement in their dissolution rates (by ~8 fold for
IBU and ~5 fold for FLU; Table IV), indicating substantially
higher solubility of the cocrystals than the corresponding profens.
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This table is from the article titled "Simultaneously Improving the Mechanical Properties, Dissolution Performance, and Hygroscopicity of Ibuprofen and Flurbiprofen by Cocrystallization with Nicotinamide"
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