Intrinsic Dissolution Rates of Cocrystal Formers and Cocrystals at 37°C in Water (n = 3)
Presented in Table IV are the intrinsic dissolution rate
As expected for BCS Class II drugs, the two profens exhibit very
slow dissolution (Table IV), consistent with their low aqueous
solubilities (Table III).
However, when forming a cocrystal with NCT, both profens displayed
substantial enhancement in their dissolution rates (by ~8 fold for
IBU and ~5 fold for FLU; Table IV), indicating substantially
higher solubility of the cocrystals than the corresponding profens.
Viewing this image requires a subscription. If you are a subscriber, please log in.
This table is from the article titled "Simultaneously Improving the Mechanical Properties, Dissolution Performance, and Hygroscopicity of Ibuprofen and Flurbiprofen by Cocrystallization with Nicotinamide"
(from Pharmaceutical Research), which is copyrighted by Springer Science+Business Media, LLC. For more information on the
copyright for this table, please refer to the full table caption and to the
The image is being made available for non-commercial purposes for subscribers to SpringerImages. For more information on what you are allowed to do with this image, please see our copyright policy.
To request permissions to use any copyrighted material, please visit the source document.
Report a copyright concern regarding this image.
Log in or register to save your favorite images and download them as high-quality PowerPoint or PDF files.
Log in or register to save your search criteria.
© Springer, part of Springer Science+Business Media.
Remote Address: 184.108.40.206 Server: 18