Effect of paradichlorobenzene (PDCB) on uterotrophic activity of β-estradiol (E2) in immature (20–22 days old) Crlj:CD-1 (ICR) mice. Single doses of E2 and PDCB in dimethyl sulfoxide were sc administered in study 13; a single ip dose of E2 in olive oil and three successive sc doses of PDCB in olive oil were administered in study 14; three successive doses of E2 and PDCB in olive oil were ip administered in studies 15–17. The number of mice of each group was seven to eight in study 13, and eight in studies 14–17. Five/eight or five/ten mice were died in 800 mg PDCB/kg/day (study 15) or 600 mg PDCB/kg/day (study 16) groups. Massive lung hemorrhage was found in all dead mice. Relative organ weights are expressed as mg per 10 g body weight. Those marked a and b (aP < 0.001; bP < 0.01) are significantly different from the vehicle control by student’s t-test or Wilcoxon rank sum test. *P < 0.05; **P < 0.01, significantly different from the E2 control by Dunnett’s test
Immature female mice were sc administered simultaneously E2
(2 μg/kg) and PDCB (0, 8, 80 and 800 mg/kg) dissolved in
DMSO (study 13 in Fig. 3 ).
When immature mice were sc administered PDCB (0, 8, 80 and
800 mg/kg/day) dissolved in olive oil for three successive
days followed by ip injection of E2 (2 μg/kg) at the third
day, a single dose of E2 in olive oil did not increase uterine
weights but PDCB decreased uterine weight in a dose-dependent
fashion (study 14 in Fig. 3 ).
Study 14 in Fig. 3 .
Study 15 in Fig. 3 .
Study 16 in Fig. 3 .
Study 17 in Fig. 3 .
Antagonistic activity of PDCB against E2 uterotrophy has been found
in mice ip administered PDCB at doses more than 400 mg/kg/day
(studies 4 and 5 in Fig. 3 ).
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